C. Mark Nichols

The paper identifies a hypometabolic CD8+ T cell state, TEff-2, linked to respiratory failure and mortality in critical illness using single-cell RNA sequencing.

This paper shows that BCL6 in T cells promotes type 1 diabetes by enabling anti-insulin B cells to become pathogenic, and that blocking BCL6 in T cells prevents diabetes even when insulin-reactive B cells are present.

This study shows that maternal inflammation during late gestation in mice alters immune responses to vaccination in adult offspring.

The paper examines metabolic adaptations in CD4 T cells of critically ill patients with and without sepsis, identifying subset-specific changes linked to immunosuppression and clinical outcomes.