Ivelin S. Georgiev

Insulin-binding B cells can arise in early-stage type 1 diabetes individuals in the absence of somatic hypermutation or insulin autoantibody seropositivity

The paper identifies anti-insulin B cells in early-stage T1D patients without autoantibodies or somatic hypermutation, showing their role in autoimmunity.

Development and application of nbLIBRA-seq for high-throughput discovery of antigen-specific nanobodies

This paper develops and validates nbLIBRA-seq, a method for high-throughput antigen-specific nanobody discovery in immunized alpacas, demonstrating its effectiveness in identifying nanobodies against CD71 and viral antigens.

Design and characterization of broadly protective influenza A(H3N2) vaccine candidates using protein language models

This study designs influenza A(H3N2) vaccine candidates using protein language models and machine learning, showing two candidates provide broad protection against current and drifted strains in mice.

Prefusion-specific glycoprotein B human antibodies protect against neonatal HSV-2 infection

The paper identifies prefusion-specific human antibodies against HSV-2 gB that neutralize both HSV-1 and HSV-2 and protect neonatal mice.

A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein

The paper identifies a human antibody that neutralizes RSV and hMPV by targeting a novel epitope spanning multiple antigenic sites, showing cross-protection in a mouse model.

Contrastive Learning Enables Epitope Overlap Predictions for Targeted Antibody Discovery

This paper develops computational methods to predict epitope overlaps in antibodies, showing improved accuracy using contrastive learning and demonstrating their utility in antibody discovery.

Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity

The paper isolates glycan-reactive antibodies from HIV-1 vaccine trial participants and finds they neutralize diverse HIV strains and show broad cross-reactivity against other pathogens.

Identification of a broad and potent V3 glycan site bNAb targeting anN332gp120 glycan-independent epitope

This paper identifies a potent, broad neutralizing antibody targeting a glycan-independent V3 epitope on HIV-1 Env, showing enhanced neutralization potency and resistance to escape mutations.

Generation of antigen-specific paired chain antibody sequences using large language models

This paper introduces MAGE, a model that generates paired human antibody sequences against specific targets, validated against SARS-CoV-2, H5N1, and RSV-A.

Discovery and Characterization of a Pan-betacoronavirus S2-binding antibody

The paper identifies a pan-betacoronavirus antibody that binds the S2 subunit of spike proteins and induces Fc-dependent antiviral responses, offering insights into non-neutralizing antibody protection.

Design of Antigen-Specific Antibody CDRH3 Sequences Using AI and Germline-Based Templates

This paper designs antigen-specific antibody CDRH3 sequences using AI and germline-based templates, validated against SARS-CoV-2.

Negative Binomial Mixture Model for Identification of Noise in Antigen-Specificity Predictions by LIBRA-seq

The paper introduces a negative binomial mixture model to denoise LIBRA-seq data, improving antigen binding predictions across multiple donors.