Author

Matthew T. Stier

Vanderbilt UniversityORCID 0000-0003-3928-1682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:cell-cell communication· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Casey M. NicholsiD· 3 shared Chooi Ying Sim· 2 shared Dawn C. NewcombiD· 2 shared Erin L. Mwizerwa· 2 shared Jeffrey C. RathmelliD· 2 shared Julie A. BastaracheiD· 2 shared Lorraine B. WareiD· 2 shared Sarah N. ObeidallaiD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Casey M. NicholsORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintAug 2, 2026

SAP loss limits anti-insulin atypical B cell activation and pro-inflammatory CD8 T cells despite preserved Tfh responses to protect against type 1 diabetes

Landon M. Clark, Dudley H. McNitt, James McAninch…·Rachel H. Bonami

DOI 10.64898/2026.07.29.741363

mouseflow cytometry

𝕏 PostBluesky

ImmunologybioRxivPreprintJun 2, 2026

Critical illness expands a transcriptionally distinct hypometabolic CD8+ T effector program associated with respiratory failure and mortality

C. Mark Nichols, Erin L. Mwizerwa, Chooi Ying Sim…·Matthew T. Stier

The paper identifies a hypometabolic CD8+ T cell state, TEff-2, linked to respiratory failure and mortality in critical illness using single-cell RNA sequencing.

DOI 10.64898/2026.05.28.728555

𝕏 PostBluesky

ImmunologyNature ImmunologyPeer-reviewedJan 15, 2026

Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without Sepsis

Matthew T. Stier, Allison E. Sewell, Erin L. Mwizerwa…·Jeffrey C. Rathmell

The paper examines metabolic adaptations in CD4 T cells of critically ill patients with and without sepsis, identifying subset-specific changes linked to immunosuppression and clinical outcomes.

17 citationstop 1%

humanbulk RNA-seq

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