TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differnetiation
Karoliina Tuomela, Rosa García, Dominic A. Boardman, Pedram Tavakoli, Maria Ancheta-Schmit, Ho Pan Sham, Lihong Cheng, Mary D. Struthers, Brian L. Bressler, Bruce Andrew Vallance, Qihong Zhao, Megan K. Levings
This study shows that TYK2 inhibition promotes Treg differentiation and function while inhibiting Th1 and Th17 differentiation, suggesting its potential for tolerance induction.
Cell Reports Medicine · Aug 19, 2025Peer-reviewedImmunology