Bruce Andrew Vallance

This study shows that bowel preparation with PEG increases susceptibility to pathogens and exacerbates inflammation in mouse and in vitro models.

This study shows that TYK2 inhibition promotes Treg differentiation and function while inhibiting Th1 and Th17 differentiation, suggesting its potential for tolerance induction.

This paper shows that disrupting mucin sugar pathways in Citrobacter rodentium leads to accumulation of N-acetylglucosamine 6-phosphate, impairing bacterial growth and pathogenesis in mice.

The paper identifies MUC17 as a critical component of the small intestinal glycocalyx that is disrupted in Crohn's disease, leading to bacterial contact and epithelial defects.

This study investigates the role of two type III secretion systems in Providencia alcalifaciens, showing their differential contributions to host interactions and pathogenicity.

This study identifies ClpP-dependent proteostasis as critical for antibiotic persistence in C. jejuni through bioenergetic homeostasis and metabolic remodeling.

This study shows that gut-derived bacterial flagellin contributes to beta-cell inflammation and dysfunction in type 2 diabetes.