Megan K. Levings

This study improves the reproducibility of antigen-specific T cell detection using standardized AIM assay workflows and automated analysis tools.

This study shows regenerative macrophages enhance beta cell survival, function, and proliferation in vitro through contact-independent mechanisms and promote a regenerative macrophage phenotype.

This study shows how to generate CD4+ T cells from pluripotent stem cells by controlling Notch and T cell receptor signaling, enabling clonally diverse and expandable cells that can differentiate into helper cell types.

The paper develops Siglec-liposomes to detect Siglec ligands and modulate immune cell function, showing they enhance T cell proliferation.

A2-CAR Tregs reduce BDC2.5 T cell engraftment, proliferation, and cytokine production, protecting mice from diabetes and inducing systemic tolerance.

This study shows that TYK2 inhibition promotes Treg differentiation and function while inhibiting Th1 and Th17 differentiation, suggesting its potential for tolerance induction.

This study engineers CAR Tregs to secrete IL-10 via PDCD1-driven regulation, enhancing their suppressive function in vitro and in vivo.

The paper describes a germline variant in IKZF2 causing immune dysregulation, including AIHA and atopic dermatitis, and reports single-cell RNA sequencing findings on T cell dysfunction.

This study shows that A2-specific CAR Tregs synergize with anti-CD154 to promote graft survival in haplo-mismatched heart transplants by inhibiting donor-specific immune responses.

The paper functionally screens IBD genes in intestinal epithelial cells to identify their roles in epithelial structure and function, revealing DUSP16's role in mucosal defense.