Author

Karoliina Tuomela

University of British ColumbiaORCID 0000-0003-1631-7435Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Dominic A. BoardmaniD· 2 shared Megan K. LevingsiD· 2 shared Andrew Brown· 1 shared Avery J. LamiD· 1 shared Brian L. BressleriD· 1 shared Bruce Andrew VallanceiD· 1 shared Christine M. WardelliD· 1 shared Ho Pan ShamiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Dominic A. BoardmanORCID

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2 papers

Recent·Most cited

ImmunologyCell Reports MedicinePeer-reviewedAug 19, 2025

TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differnetiation

Karoliina Tuomela, Rosa García, Dominic A. Boardman…·Megan K. Levings

This study shows that TYK2 inhibition promotes Treg differentiation and function while inhibiting Th1 and Th17 differentiation, suggesting its potential for tolerance induction.

14 citationstop 4%

humanbulk RNA-seq

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ImmunologyScience AdvancesPeer-reviewedJun 13, 2025

Fourth generation CAR Tregs with PDCD1-driven IL-10 have enhanced suppressive function

Dominic A. Boardman, Sonya Mangat, Jana K. Gillies…·Megan K. Levings

This study engineers CAR Tregs to secrete IL-10 via PDCD1-driven regulation, enhancing their suppressive function in vitro and in vivo.

18 citationstop 2%

humangenetic perturbation / CRISPR

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