Profilin 1 maintains cell cycle fidelity to prevent unscheduled genome doubling and polyploidy in cancer
Federica Scotto di Carlo, Sharon Russo, Simon Gemble, Noemi Vitale, Anne‐Sophie Macé, Iris Harmsen, Maria Assunta Borriello, Floris Foijer, Marcello Manfredi, Renata Basto, Fernando Gianfrancesco
This study identifies Profilin 1 as a safeguard against genome doubling and polyploidy in cancer by showing its role in maintaining cell cycle fidelity and preventing therapeutic resistance.
bioRxiv · May 15, 2026 · PreprintCancer Biology