Renata Basto

The paper investigates how different routes to whole-genome duplication (WGD) affect nuclear stability, finding that mitotic slippage uniquely causes nuclear instability.

This study identifies Profilin 1 as a safeguard against genome doubling and polyploidy in cancer by showing its role in maintaining cell cycle fidelity and preventing therapeutic resistance.

This study identifies a novel role for Gen nuclease in promoting polyploid cell proliferation unrelated to DNA repair, by influencing DNA replication rates in non-physiological polyploidy.

The paper identifies a novel centrosome elimination mechanism in Drosophila polyploid cells that supports metabolic activity by preserving mitochondrial function.

This study shows that biomechanical stress in embryonic neural progenitors affects mitotic fidelity through cortical actin and tension.

The paper identifies a novel form of gene expression instability, called Illuminati, in Drosophila neural stem cells, showing it is environmentally influenced and can persist through multiple cell cycles.