Effects of sheared chromatin length on ChIP-seq quality and sensitivity
Cheryl A. Keller, Alexander Q. Wixom, Elisabeth F. Heuston, Belinda M. Giardine, Chris C.‐S. Hsiung, Maria Long, Amber Miller, Stacie M. Anderson, April Cockburn, Gerd A. Blobel, David M. Bodine, Ross C. Hardison
This study investigates how chromatin shearing affects ChIP-seq quality and shows that sonication levels significantly impact signal quality and specificity for different transcription factors.
G3 Genes Genomes Genetics · Mar 31, 2021Peer-reviewedGenomics