A trans-translation inhibitor kills Mycobacterium tuberculosis by targeting ribosomal protein bL12
Akanksha Varshney, John N. Alumasa, Amber Miller, Kenneth C. Keiler
This study identifies KKL-1005 as a trans-translation inhibitor that targets ribosomal protein bL12 in Mycobacterium tuberculosis, showing it specifically disrupts the trans-translation pathway.
bioRxiv · Jun 2, 2025 · PreprintMicrobiology