Author

Chris C.‐S. Hsiung

University of California, San FranciscoORCID 0000-0002-1366-6069Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Abolfazl ArabiD· 1 shared Alexander Q. WixomiD· 1 shared Amber Miller· 1 shared April Cockburn· 1 shared Belinda M. GiardineiD· 1 shared Caroline M. WilsoniD· 1 shared Cheryl A. KelleriD· 1 shared David M. BodineiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetics

Abolfazl ArabORCID

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2 papers

Recent·Most cited

GeneticsNature BiotechnologyPeer-reviewedMay 17, 2024

Higher-order combinatorial chromatin perturbations by engineered CRISPR-Cas12a for functional genomics

Chris C.‐S. Hsiung, Caroline M. Wilson, Nicholas A. Sambold…·Luke A. Gilbert

The paper introduces multiAsCas12a, an engineered CRISPR-Cas12a variant enabling higher-order combinatorial chromatin perturbations, and demonstrates its use in discovering new enhancer elements and dissecting cis-regulatory element functions.

53 citationstop 1%

CRISPR screenexperimental assay

𝕏 PostBluesky

GenomicsG3 Genes Genomes GeneticsPeer-reviewedMar 31, 2021

Effects of sheared chromatin length on ChIP-seq quality and sensitivity

Cheryl A. Keller, Alexander Q. Wixom, Elisabeth F. Heuston…·Ross C. Hardison

This study investigates how chromatin shearing affects ChIP-seq quality and shows that sonication levels significantly impact signal quality and specificity for different transcription factors.

11 citations

mouseChIP-seq

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