Characterization of a novel mouse model of Dopamine Transporter Deficiency Syndrome and pharmacological therapeutic strategies
Emma E. Russo, Ameneh Rezayof, Conner W. Wallace, Erin Q. Williams, Pieter Beerepoot, Marija Milenkovic, Maria Novalen, Aled Blundell, Tatiana V. Lipina, Jason L. Locke, Raveen Christian, Peter S.B. Finnie, Landon J. Edgar, Rachel Fynvola Tyndale, Dawn E. Watkins‐Chow, , Ali Salahpour
This study creates a mouse model of DTDS with the A313V DAT variant and identifies two potential treatments, [a]MPT and AMPH, that reduce hyperactivity.
bioRxiv · Mar 21, 2025 · PreprintPharmacology & Toxicology