Author

Jason L. Locke

Wake Forest University Health Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:human· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Sara R. JonesiD· 3 shared Aled Blundell· 1 shared Ali SalahpouriD· 1 shared Alyson M. CurryiD· 1 shared Alyssa M. WestiD· 1 shared Ameneh RezayofiD· 1 shared Amy J. RamseyiD· 1 shared Brian A. McCooliD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Sara R. JonesORCID

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Author profile →

3 papers

Recent·Most cited

Characterization of a novel mouse model of Dopamine Transporter Deficiency Syndrome and pharmacological therapeutic strategies

Emma E. Russo, Ameneh Rezayof, Conner W. Wallace, Erin Q. Williams, Pieter Beerepoot, Marija Milenkovic, Maria Novalen, Aled Blundell, Tatiana V. Lipina, Jason L. Locke, Raveen Christian, Peter S.B. Finnie, Landon J. Edgar, Rachel Fynvola Tyndale, Dawn E. Watkins‐Chow, , Ali Salahpour

This study creates a mouse model of DTDS with the A313V DAT variant and identifies two potential treatments, [a]MPT and AMPH, that reduce hyperactivity.

bioRxiv · Mar 21, 2025 · PreprintPharmacology & Toxicology

Synaptogyrin-3 Prevents Cocaine Addiction and Dopamine Deficits

Emily G. Peck, Katherine M. Holleran, Alyson M. Curry, Kimberly M. Holter, Paige M. Estave, Jonathon P. Sens, Jason L. Locke, Olivia A. Ortelli, Brianna E. George, Monica H. Dawes, Alyssa M. West, Nancy J. Alexander, Drew D. Kiraly, Sean P. Farris, Robert W. Gould, , Sara R. Jones

This study shows that synaptogyrin-3 reduces cocaine self-administration and prevents dopamine deficits by enhancing dopamine signaling and cognitive flexibility in rats.

bioRxiv · Jul 27, 2024 · PreprintNeuroscience

Stress-induced alterations of norepinephrine release in the bed nucleus of the stria terminalis of mice

Karl T. Schmidt, Viren H. Makhijani, Kristen M. Boyt, Elizabeth S. Cogan, Dipanwita Pati, Melanie M. Pina, Isabel M. Bravo, Jason L. Locke, Sara R. Jones, Joyce Besheer, Zoé A. McElligott

The paper examines how repeated stress affects norepinephrine release in the BNST of mice, finding increased release and reduced autoreceptor sensitivity.

ACS Chemical Neuroscience · Sep 25, 2018Peer-reviewedNeuroscience