Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets
Jordan A. Bairos, Uche Chinedu Njoku, Maria Zafar, May G. Akl, Lei Li, Güneş Parlakgül, Ana Paula Arruda, Scott B. Widenmaier
This study shows that SOAT1-mediated cholesterol esterification is required for cholesterol crystal formation in hepatocyte lipid droplets, linking it to MASH pathogenesis.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · May 16, 2024Peer-reviewedMolecular Biology