Scott B. Widenmaier

This study shows monounsaturated fats reduce cholesterol crystals in lipid droplets, while saturated fats promote their formation in mice with MASH.

This study identifies ER-PM contacts and STIM-mediated SOCE as essential for brown fat thermogenesis and metabolic health during cold exposure.

This study shows hepatic Nrf1 promotes VLDL-dependent liver defense against sepsis by enhancing stress defenses and improving survival.

This study identifies the Nfe2l1-Atf3 pathway as a regulator of cholesterol-induced adipocyte inflammation and insulin resistance in both human and mouse models.

This study shows that SOAT1-mediated cholesterol esterification is required for cholesterol crystal formation in hepatocyte lipid droplets, linking it to MASH pathogenesis.