Molecular BiologyBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsPeer-reviewed
Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets
Jordan A. Bairos, Uche Chinedu Njoku, Maria Zafar…·Scott B. Widenmaier
This study shows that SOAT1-mediated cholesterol esterification is required for cholesterol crystal formation in hepatocyte lipid droplets, linking it to MASH pathogenesis.