Ana Paula Arruda

This study identifies ER-PM contacts and STIM-mediated SOCE as essential for brown fat thermogenesis and metabolic health during cold exposure.

This study identifies CLCC1 as a regulator of hepatic neutral lipid flux and nuclear pore complex assembly through CRISPR screens and functional analyses.

This study identifies PPARα as a regulator of liver proteostasis, showing it suppresses protein synthesis and secretion while enhancing proteasome activity and degradation.

This study shows that SOAT1-mediated cholesterol esterification is required for cholesterol crystal formation in hepatocyte lipid droplets, linking it to MASH pathogenesis.