Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
Ashley C. Bolte, Arun B. Dutta, Mariah E. Hurt, Igor Smirnov, Michael A. Kovacs, Celia A. McKee, Hannah E. Ennerfelt, Daniel A. Shapiro, Bao Nguyen, Elizabeth L. Frost, Catherine Rose Lammert, Jonathan Kipnis, John R. Lukens
This study shows that traumatic brain injury causes severe and prolonged meningeal lymphatic dysfunction, leading to increased neuroinflammation and cognitive deficits.
Nature Communications · Sep 10, 2020Peer-reviewedNeuroscience