Igor Smirnov

The paper shows that CNS macrophage engraftment depends on TRM self-renewal and niche timing, not prolonged vacancy, and identifies a peripheral BAM-like macrophage population in aged human brains.

The paper identifies distinct transcriptional and epigenetic profiles of brain-engrafted monocyte-derived macrophages compared to microglia, showing their origin from peripheral blood and skull bone marrow.

The paper shows that IL-4R on GABAergic neurons mediates T cell effects on memory through synaptic plasticity and fear memory.

This study shows that traumatic brain injury causes severe and prolonged meningeal lymphatic dysfunction, leading to increased neuroinflammation and cognitive deficits.