Jonathan Kipnis

This study shows that reducing APOE4 in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and improves vascular function in a mouse model.

The paper shows that CNS macrophage engraftment depends on TRM self-renewal and niche timing, not prolonged vacancy, and identifies a peripheral BAM-like macrophage population in aged human brains.

The paper identifies distinct transcriptional and epigenetic profiles of brain-engrafted monocyte-derived macrophages compared to microglia, showing their origin from peripheral blood and skull bone marrow.

This study engineers CAR T cells to promote tissue repair in CNS injury by modulating immune responses and reducing inflammation.

This study shows that CAR T cell therapy in mice causes cognitive impairment through CNS immune dysregulation, microglial reactivity, and disrupted oligodendroglial homeostasis.

The paper identifies two distinct pathways for replenishing resident peritoneal macrophages after injury, with differing reliance on monocytes and intermediate stages.

This paper develops an inducible genetic tool to study microglial states in development and disease, revealing their plasticity and functional roles.

The paper shows that IL-4R on GABAergic neurons mediates T cell effects on memory through synaptic plasticity and fear memory.

This study shows that traumatic brain injury causes severe and prolonged meningeal lymphatic dysfunction, leading to increased neuroinflammation and cognitive deficits.