Pro-cognitive reshaping of neuronal dynamics by a human CSF-based factor
Marc Dos Santos, Marc P. Forrest, Ewa K. Bomba-Warczak, Euan Parnell, Seby Louis Edassery, Kun Yang, Lindsay N. Hayes, Jennifer Marie Coughlin, Blair L. Eckman, Catherine Rose Lammert, María Dolores Martin‐de‐Saavedra, Maria V. Barbolina, Akira Sawa, Jeffrey N. Savas, Peter Penzes
This study identifies a soluble synaptic protein, 2{delta}-1, reduced in schizophrenia CSF, which enhances neuronal network dynamics and cognitive function when administered to a mouse model.
bioRxiv · Dec 26, 2024 · PreprintNeuroscience