Author

Michael A. Kovacs

National Institutes of HealthORCID 0000-0002-4298-9609Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 7 Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:gene regulatory network inference· 4 Research Focus:differential expression· 3 Assay:GWAS summary statistics· 3 Organism:mouse· 3 Approach:experimental assay· 2

Frequent Co-Authors

Jiyeon ChoiiD· 5 shared Kevin M. BrowniD· 5 shared Tongwu ZhangiD· 5 shared Mai XuiD· 4 shared Mark Martin IlesiD· 4 shared Matthew H. LawiD· 4 shared Alisa M. GoldsteiniD· 3 shared Arun B. DuttaiD· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersGenetics

Jiyeon ChoiORCID

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8 papers

Recent·Most cited

The meningeal transcriptional response to traumatic brain injury and aging

Ashley C. Bolte, Daniel A Shapiro, Arun B. Dutta, Wei Feng, Katherine R. Bruch, Michael A. Kovacs, Ana Royo Marco, Hannah E. Ennerfelt, John R. Lukens

This study investigates the meningeal transcriptional response to traumatic brain injury and aging using scRNA-seq and bulk RNA-seq in mice, revealing age-related differences in immune and extracellular matrix gene expression.

eLife · Dec 15, 2022Peer-reviewedNeuroscience

Regulation of neuroinflammation by astrocyte-derived cholesterol.

Hao Wang, Joshua A. Kulas, Yang Yu, Joshua L. Milstein, Claire E. Peng, Holden Higginbotham, Jed Robert Christensen, Michael A. Kovacs, Anton M. Schüle, Denys Oliinyk, Thierry M. Nordmann, Matthias Mann, Adriano Aguzzi, Heather Anne Ferris, Scott B. Hansen

This study shows that astrocyte-derived cholesterol, released via apoE, promotes neuroinflammation by enhancing inflammatory signaling in immune cells.

bioRxiv · Dec 12, 2022 · PreprintNeuroscience

Investigating the genetic architecture of eye colour in a Canadian cohort

Frida Lona‐Durazo, Rohit Thakur, Erola Pairo‐Castineira, Karen M. Funderburk, Tongwu Zhang, Michael A. Kovacs, Jiyeon Choi, Ian J. Jackson, Kevin M. Brown, Esteban Juan Parra

This study identifies genetic loci associated with eye colour in a Canadian European cohort, highlighting the HERC2/OCA2 region and other genes, and explores their molecular mechanisms.

iScience · May 30, 2022Peer-reviewedGenetics

A UVB-responsive common variant at chr7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor gene (AHR)

Mai Xu, Lindsey Catherine Mehl, Tongwu Zhang, Rohit Thakur, Hayley Sowards, Timothy A. Myers, Lea Jessop, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Helen T. Michael, Patricia Bunda, Kristine M. Jones, Herbert Higson, Rebecca C. Hennessey, , Kevin M. Brown

This paper identifies rs117132860 as a functional variant at 7p21.1 that regulates AHR expression in response to UVB, contributing to melanoma risk and tanning ability.

The American Journal of Human Genetics · Aug 2, 2021Peer-reviewedGenetics

Cell type-specific meQTL extends melanoma GWAS annotation beyond eQTL and informs melanocyte gene regulatory mechanisms

Tongwu Zhang, Jiyeon Choi, Ramile Dilshat, Berglind Osk Einarsdottir, Michael A. Kovacs, Mai Xu, Michael Malasky, Salma Chowdhury, Kristine M. Jones, David Timothy Bishop, Alisa M. Goldstein, Mark Martin Iles, Maria Teresa Landi, Matthew H. Law, Jianxin Shi, , Kevin M. Brown

The paper identifies cell-type-specific meQTLs in melanocytes and melanomas, enhancing GWAS annotation and revealing regulatory mechanisms involving IRF4.

The American Journal of Human Genetics · Jul 21, 2021Peer-reviewedGenetics

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

Ashley C. Bolte, Arun B. Dutta, Mariah E. Hurt, Igor Smirnov, Michael A. Kovacs, Celia A. McKee, Hannah E. Ennerfelt, Daniel A. Shapiro, Bao Nguyen, Elizabeth L. Frost, Catherine Rose Lammert, Jonathan Kipnis, John R. Lukens

This study shows that traumatic brain injury causes severe and prolonged meningeal lymphatic dysfunction, leading to increased neuroinflammation and cognitive deficits.

Nature Communications · Sep 10, 2020Peer-reviewedNeuroscience

Massively parallel reporter assays combined with cell-type specific eQTL informed multiple melanoma loci and identified a pleiotropic function of HIV-1 restriction gene, MX2, in melanoma promotion

Jiyeon Choi, Tongwu Zhang, Andrew H. Vu, Julien Ablain, Matthew M. Makowski, Leandro Machado Colli, Mai Xu, Rebecca C. Hennessey, Jinhu Yin, Harriet Rothschild, Cathrin Gräwe, Michael A. Kovacs, Karen M. Funderburk, Myriam Brossard, John Taylor, , Kevin M. Brown

The paper identifies multiple melanoma susceptibility genes and variants by integrating MPRA with eQTL data, revealing MX2's role in melanoma promotion.

Nature Communications · Jun 1, 2020Peer-reviewedGenomics

Cell-type specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes

Tongwu Zhang, Jiyeon Choi, Michael A. Kovacs, Jianxin Shi, Mai Xu, NISC Comparative Sequencing Program, Alisa M. Goldstein, Adam J. Trower, David Timothy Bishop, Mark Martin Iles, David L. Duffy, Stuart MacGregor, Laufey Thora Amundadottir, Matthew H. Law, Stacie K. Loftus, , Kevin M. Brown

The paper identifies cell-type specific eQTLs in primary melanocytes, revealing novel melanoma susceptibility genes and associations with GWAS loci.

Genome Research · Nov 1, 2018Peer-reviewedGenetics