Alzheimer's disease causes bone marrow myelopoiesis dysfunction
Miguel Angel Abellanas, Leyre Basurco, Maitreyee Purnapatre, Chiara Burgaletto, Giulia Castellani, Sarah Phoebeluc Colaiuta, Javier María Peralta Ramos, Angham Ibraheem, Sama Murad, Paola Antonello, Mariangeles Kovacs, Yuliya Androsova, Bar Nathansohn, Hannah Partney, Liora Cahalon, , Michal Schwartz
This study identifies impaired bone marrow myelopoiesis in Alzheimer's disease, driven by type I interferon signaling, and shows that targeting this pathway improves myeloid function and cognitive outcomes.
bioRxiv · Oct 6, 2025 · PreprintNeuroscience