Systemic administration of PD-L1 blocking antibodies leads to removal of senescent microglia
Yuliya Androsova, Alexander Kertser, Hannah Partney, Bar Nathansohn, Angham Ibraheem, Miguel Angel Abellanas, Tommaso Croese, Tomer Meir Salame, Hagay Akiva, Valery Krizhanovsky, Michal Schwartz
The paper shows that systemic PD-L1 blockade removes senescent microglia in mice, reducing neuroinflammation and suggesting a therapeutic role in Alzheimer's disease.
bioRxiv · Dec 24, 2025 · PreprintNeuroscience