Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation and its reversal by selective PDE11A4-targeted small molecules in cells and brain
Elvis Amurrio, Janvi Patel, Marie Danaher, Helen Do, Laila Elzaree, Janet L. Fisher, Haley Greene, Porschderek Kargbo, Priscilla Kim, Eliska Klimentova, Yan Liu, Mohammed Yusef Mehboob, Suad Abdella, Yadiel Temesgen, Wenbo Yu, , Michy P. Kelly
This study identifies molecular mechanisms regulating PDE11A4 liquid-liquid phase separation and shows that PDE11A inhibitors can reverse it in cells and brain.
bioRxiv · May 20, 2025 · PreprintNeuroscience