Author

Porschderek Kargbo

University of Maryland, Baltimore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Neuroscience· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Organism:human· 1

Frequent Co-Authors

Elvis Amurrio· 3 shared Janvi Patel· 3 shared Janet L. Fisher· 2 shared Michy P. KellyiD· 2 shared Ana PocivavsekiD· 1 shared Beerend H. J. WinkelmaniD· 1 shared Caroline C. W. KlaveriD· 1 shared Chris I. De ZeeuwiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Elvis Amurrio

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Age-related increases in PDE11A4 protein expression trigger liquid:liquid phase separation (LLPS) of the enzyme that can be reversed by PDE11A4 small molecules inhibitors

Elvis Amurrio, Janvi Patel, M Danaher, M Goodwin, Porschderek Kargbo, S Lin, CS Hoffman, S Ul Mahmood, DP Rotella, MP Kelly

This study shows that age-related PDE11A4 protein clustering in the hippocampus is due to liquid:liquid phase separation, which can be reversed by PDE11A inhibitors in vitro and in vivo.

Cells · Jun 13, 2025Peer-reviewedNeuroscience

Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation and its reversal by selective PDE11A4-targeted small molecules in cells and brain

Elvis Amurrio, Janvi Patel, Marie Danaher, Helen Do, Laila Elzaree, Janet L. Fisher, Haley Greene, Porschderek Kargbo, Priscilla Kim, Eliska Klimentova, Yan Liu, Mohammed Yusef Mehboob, Suad Abdella, Yadiel Temesgen, Wenbo Yu, , Michy P. Kelly

This study identifies molecular mechanisms regulating PDE11A4 liquid-liquid phase separation and shows that PDE11A inhibitors can reverse it in cells and brain.

bioRxiv · May 20, 2025 · PreprintNeuroscience

The sleep quality- and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the enzyme

Irina Sbornova, Emilie van der Sande, Snezana Milosavljevic, Elvis Amurrio, Steven D. Burbano, Prosun Das, H. Helen, Janet L. Fisher, Porschderek Kargbo, Janvi Patel, Latarsha Porcher, Chris I. De Zeeuw, Magda A. Meester‐Smoor, Beerend H. J. Winkelman, Caroline C. W. Klaver, , Michy P. Kelly

This paper investigates the impact of the PDE11A-Y727C variant on neural physiology, showing reduced catalytic activity and altered subcellular compartmentalization without significant effects on eye growth or sleep quality.

Cells · Dec 14, 2023Peer-reviewedNeuroscience