Janvi Patel

Age-related increases in PDE11A4 protein expression trigger liquid:liquid phase separation (LLPS) of the enzyme that can be reversed by PDE11A4 small molecules inhibitors

This study shows that age-related PDE11A4 protein clustering in the hippocampus is due to liquid:liquid phase separation, which can be reversed by PDE11A inhibitors in vitro and in vivo.

Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation and its reversal by selective PDE11A4-targeted small molecules in cells and brain

This study identifies molecular mechanisms regulating PDE11A4 liquid-liquid phase separation and shows that PDE11A inhibitors can reverse it in cells and brain.

The sleep quality- and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the enzyme

This paper investigates the impact of the PDE11A-Y727C variant on neural physiology, showing reduced catalytic activity and altered subcellular compartmentalization without significant effects on eye growth or sleep quality.