Author

Janet L. Fisher

University of South Carolina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Michy P. KellyiD· 3 shared Elvis Amurrio· 2 shared Janvi Patel· 2 shared Latarsha Porcher· 2 shared Porschderek Kargbo· 2 shared Steven D. Burbano· 2 shared Aleksandra Vidojevic· 1 shared Ana PocivavsekiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Michy P. KellyORCID

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Author profile →

4 papers

Recent·Most cited

Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation and its reversal by selective PDE11A4-targeted small molecules in cells and brain

Elvis Amurrio, Janvi Patel, Marie Danaher, Helen Do, Laila Elzaree, Janet L. Fisher, Haley Greene, Porschderek Kargbo, Priscilla Kim, Eliska Klimentova, Yan Liu, Mohammed Yusef Mehboob, Suad Abdella, Yadiel Temesgen, Wenbo Yu, , Michy P. Kelly

This study identifies molecular mechanisms regulating PDE11A4 liquid-liquid phase separation and shows that PDE11A inhibitors can reverse it in cells and brain.

bioRxiv · May 20, 2025 · PreprintNeuroscience

The sleep quality- and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the enzyme

Irina Sbornova, Emilie van der Sande, Snezana Milosavljevic, Elvis Amurrio, Steven D. Burbano, Prosun Das, H. Helen, Janet L. Fisher, Porschderek Kargbo, Janvi Patel, Latarsha Porcher, Chris I. De Zeeuw, Magda A. Meester‐Smoor, Beerend H. J. Winkelman, Caroline C. W. Klaver, , Michy P. Kelly

This paper investigates the impact of the PDE11A-Y727C variant on neural physiology, showing reduced catalytic activity and altered subcellular compartmentalization without significant effects on eye growth or sleep quality.

Cells · Dec 14, 2023Peer-reviewedNeuroscience

Unexpected proteinopathies in hippocampal PDE11A4 promote age-related cognitive decline of social associative memories

Katy Pilarzyk, Latarsha Porcher, William R. Capell, Steven D. Burbano, J Davis, Janet L. Fisher, Nicole Gorny, Siena Petrolle, Michy P. Kelly

This study identifies age-related PDE11A4 proteinopathies in the hippocampus as contributors to cognitive decline in social associative memories.

Aging Cell · Sep 8, 2022Peer-reviewedNeuroscience

Potential combined pro-cognitive, anxiolytic and antidepressant properties of novel GABAA receptor positive modulators with preferential efficacy at the α5-subunit

Thomas D. Prevot, Guanguan Li, Aleksandra Vidojevic, Keith A. Misquitta, Corey Fee, Anja Santrac, Daniel E. Knutson, Michael R. Stephen, Revathi Kodali, Nicolas M. Zahn, Leggy A. Arnold, Petra Scholze, Janet L. Fisher, Bojan D. Marković, Mounira Banasr, , Etienne Sibille

This study identifies three novel GABAA receptor modulators that show anxiolytic, antidepressant, and pro-cognitive effects in mice, unlike diazepam.

bioRxiv · May 29, 2018 · PreprintPharmacology & Toxicology