Michy P. Kelly

The paper examines age-related increases in IL-1β and IL-6 across multiple mouse eye segments and finds strong correlations between these cytokines within and across segments.

This study identifies molecular mechanisms regulating PDE11A4 liquid-liquid phase separation and shows that PDE11A inhibitors can reverse it in cells and brain.

This paper investigates the impact of the PDE11A-Y727C variant on neural physiology, showing reduced catalytic activity and altered subcellular compartmentalization without significant effects on eye growth or sleep quality.

This study identifies age-related PDE11A4 proteinopathies in the hippocampus as contributors to cognitive decline in social associative memories.

The paper shows that disrupting PDE11A4 homodimerization in hippocampal CA1 reverses age-related PDE11A4 accumulation and cognitive decline of social memory.