Structure of zebrafish NLRP3 reveals a novel mode of inflammasome activation
Lisa S. Dopslaff, Maria Mateo Tortola, Varvara Varlamova, Corinna Gehring-Khav, Marit Walle, Lukas SCHENK, A Weber, Veit Hornung, Liudmila Andreeva
This study reports a novel mode of NLRP3 activation in zebrafish through cryo-EM structure analysis, revealing a distinct oligomeric arrangement and activation mechanism compared to humans.
bioRxiv · Apr 21, 2026 · PreprintImmunology