Maria Mateo Tortola

This study reports a novel mode of NLRP3 activation in zebrafish through cryo-EM structure analysis, revealing a distinct oligomeric arrangement and activation mechanism compared to humans.

This study shows that NLRP3 directly senses intracellular potassium ions, with K+ levels regulating its conformation and inflammasome activation.

This paper shows that BTK and MMP-9 negatively regulate NLRP3 inflammasome activity in neutrophils, affecting cytokine and NET release.

The paper identifies two distinct NLRP3 activation pathways, one dependent on decameric cage formation and another independent of the MTOC and TGN.