Bone Marrow Adipokine Mediates Hematopoietic Regeneration and Stem Cell Fitness
Parash Prasad, Angelo D’Alessandro, Abhishek K. Singh, Yi Zheng, John P. Manis, Li Chai, Mohd Kamran, Mark Soliman, Ashley M. Wellendorf, Leo Mejia, Hongbo Robert Luo, Sean R. Stowell, Shin‐Young Park, Martin J. Aryee, Mercedes Ricote, , José A. Cancelas
This study identifies BM adipocyte-derived Resistin, regulated by RXR signaling, as critical for HSC self-renewal and hematopoietic regeneration after myeloablation.
bioRxiv · Aug 28, 2025 · PreprintPhysiology