Yi Zheng

This study identifies PKCδ agonism as a method to selectively induce pyroptosis in NF1-deficient cells by targeting KRAS-GDP interactions.

This study shows that the level of myeloid skewing in blood correlates with biological aging and disease in mice and humans.

This study identifies tonic signaling as a key factor in CAR-T cell efficacy for diffuse midline glioma, showing that restrained tonic signaling improves therapeutic outcomes.

This paper discovers and characterizes SH6, a small molecule degrader of ZBTB7A that increases fetal hemoglobin expression in erythroid cells and shows therapeutic potential for β-hemoglobinopathies.

This study identifies BM adipocyte-derived Resistin, regulated by RXR signaling, as critical for HSC self-renewal and hematopoietic regeneration after myeloablation.

This study shows that reducing RhoA activity in aged HSCs lowers nuclear tension, restores chromatin structure, and improves regenerative capacity and lineage balance.

This study shows that loss of Cdc42 in mice causes defects in optic cup morphogenesis, leading to microphthalmia and coloboma due to impaired cell polarity, junctions, and proliferation.

This study identifies endothelial RhoA activation as a key driver of tumor cell transendothelial migration and metastasis, showing it can be inhibited to reduce metastatic potential.

This paper introduces ceSAR, a method combining docking and transcriptional signature connectivity to improve drug discovery and repurposing by reducing false positives and computational costs.

This study identifies a Cdc42-Borg4-Sep7 axis that regulates HSC polarity and function by controlling the polar distribution of these proteins and affecting engraftment potential and LMPP frequency.