BioengineeringbioRxivPreprint
Innate immunocompetent iNSpheroids: A hiPSC-derived 3D model to study the central nervous system captures an early CNS response to rAAV
Catarina Monteiro Gomes, Gabriela Priscila de Lima Silva, Mafalda M Aleixo…·Catarina Brito
The paper develops a 3D human CNS model from hiPSCs to study immune responses to rAAV gene therapy, finding that iMGL-iNSpheroids show mild, transient inflammation to rAAV9.
DOI 10.1101/2025.07.07.662807