Interlaboratory benchmarking of differential scanning fluorimetry reveals sources of variability in protein thermal stability parameters
Sébastien Brûlé, Maelenn Chevreuil, Osvaldo Burastero, Olga Abián, Gregor Anderluh, Magali Nicaise, Martynas Bagdonas, Holly L. Birchenough, Alexander Kai Buell, Tatsiana Charnavets, Audrey Crousilles, Nataliya Danilenko, Markus Epe, Edoardo Fabini, Alessandra Feoli, , Bertrand D. E. Raynal
This study benchmarks DSF across labs, showing variability in thermal stability parameters due to instruments, workflows, and fluorescence readouts, with harmonization and centralized analysis improving consistency.
bioRxiv · Oct 13, 2026 · PreprintBiophysics