Author

Sébastien Brûlé

Institut PasteurORCID 0000-0002-8797-6748Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Magali NicaiseiD· 2 shared Adrián Velázquez‐CampoyiD· 1 shared Alessandra FeoliiD· 1 shared Alexander Kai BuelliD· 1 shared Alexis Kuntzmann· 1 shared Aline Le RoyiD· 1 shared Andre Hubertus Mueller· 1 shared André MatagneiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

Magali NicaiseORCID

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2 papers

Recent·Most cited

Interlaboratory benchmarking of differential scanning fluorimetry reveals sources of variability in protein thermal stability parameters

Sébastien Brûlé, Maelenn Chevreuil, Osvaldo Burastero, Olga Abián, Gregor Anderluh, Magali Nicaise, Martynas Bagdonas, Holly L. Birchenough, Alexander Kai Buell, Tatsiana Charnavets, Audrey Crousilles, Nataliya Danilenko, Markus Epe, Edoardo Fabini, Alessandra Feoli, , Bertrand D. E. Raynal

This study benchmarks DSF across labs, showing variability in thermal stability parameters due to instruments, workflows, and fluorescence readouts, with harmonization and centralized analysis improving consistency.

bioRxiv · Oct 13, 2026 · PreprintBiophysics

Ecological Diversification into Broad Thermal Niches Revealed by Protein Resurrection and Proteome-Wide Ancestral Reconstruction During the Rapid Radiation of Alvinellid Worms

Pierre-Guillaume Brun, Anne‐Sophie Le Port, Marion Ballenghien, Sébastien Brûlé, Magali Nicaise, Lionel Cladière, Didier Jollivet, Jean Mary

This study uses protein resurrection and ancestral reconstruction to show that Alvinellid worms' last common ancestor had highly stable proteins, similar to modern thermotolerant species, revealing how they diversified into thermal niches.

bioRxiv · Jul 30, 2026 · PreprintEvolutionary Biology