Bertrand D. E. Raynal

This study benchmarks DSF across labs, showing variability in thermal stability parameters due to instruments, workflows, and fluorescence readouts, with harmonization and centralized analysis improving consistency.

The paper characterizes the regulatory mechanism of class II bacterial IMPDH from Burkholderia thailandensis, showing MgGTP's dual role in enzyme activity and oligomerization.

This study identifies trehalose as an activator of ClpC1P1P2 and ClpXP1P2 protease complexes in Mycobacterium tuberculosis, revealing a new mechanism for in vivo activation without the need for peptide activators.

This study defines the structural basis of MfpD function using phylogenetic, structural, and biophysical approaches, revealing its role in promoting GTP hydrolysis by MfpB through a noncanonical mechanism.

This study presents the cryo-EM structure of inactive ADGRV1 and shows it has weak constitutive activation and an alternative activation mechanism distinct from other aGPCRs.

This study identifies L. pneumophila's LpDot1 protein as a bacterial effector that modifies SFPQ, disrupting paraspeckle organization and host splicing, leading to alternative splice variants of infection-related genes.

This study investigates the incomplete lytic cycle of hankyphage, a Bacteroides bacteriophage, revealing defective virion formation and incomplete DNA packaging.