Triptans reprogram Schwann cells to drive medication-overuse headache via β-glycan/TGF-β3 signaling
Martina Chieca, Matilde Marini, Marta Baragli, Elisa Bellantoni, Lorenzo Bonacchi, Francesco De Cesaris, Cristina Tassorelli, Roberto De Icco, Rosaria Greco, Lucrezia Timotei, Beatrice Pulli, Giuseppe Spinelli, Daniel Souza Monteiro de Araújo, Alice Papini, Gaetano De Siena, , Francesco De Logu
This study identifies Schwann cell 5-HT1B/D signaling as a dual mediator of triptan efficacy and medication-overuse headache via TGF-β3-driven proalgesic pathways.
bioRxiv · Apr 28, 2026 · PreprintPharmacology & Toxicology