Romina Nassini

Endocytosis and Compartmentalized Intracellular Signaling of the Prostaglandin Receptor EP4 Mediate Pain

This study shows that EP4 receptor internalization and compartmentalized signaling in DRG nociceptors mediate PGE2-induced pain, suggesting new strategies for inflammatory pain management.

Schwann cell p75NTR sustains persistent pain downstream to NGF through ROS-dependent TRPA1 signaling

The paper identifies a Schwann cell p75NTR-ROS-TRPA1 pathway that sustains persistent pain downstream of NGF, highlighting non-neuronal p75NTR signaling as a therapeutic target.

Targeting Synaptic Vesicle Endocytosis in Nociceptors Provides Sustained Pain Relief

This study identifies synaptic vesicle endocytosis in nociceptors as a driver of chronic pain and shows that targeting it with CRISPR/dCas9-R via lipid nanoparticles provides long-lasting pain relief without affecting acute pain responses.

Triptans reprogram Schwann cells to drive medication-overuse headache via β-glycan/TGF-β3 signaling

This study identifies Schwann cell 5-HT1B/D signaling as a dual mediator of triptan efficacy and medication-overuse headache via TGF-β3-driven proalgesic pathways.

Disentangling Schwann Cell and Neuronal TRPA1 Function in Mouse Models of Familial Episodic Pain Syndrome

This study investigates the cell-specific roles of mutant TRPA1 in FEPS using mouse models, showing distinct contributions of neuronal and Schwann cell TRPA1 to pain mechanisms.

Targeting the Schwann Cell EP2/cAMP Nanodomain to Block Pain but not Inflammation

The paper identifies a druggable EP2 receptor in Schwann cells that encodes PG-mediated persistent inflammatory pain without affecting protective inflammation.

PoreMeth2: decoding the evolution of methylome alterations with Nanopore sequencing

PoreMeth2 identifies differentially methylated regions using Nanopore sequencing, revealing epigenomic changes in cancer and glial cells.