NicheSphere reveals Spp1⁺ macrophages as central hubs coordinating fibrotic remodeling in myeloproliferative neoplasms
Hélène F.E. Gleitz, Mayra L. Ruiz Tejada Segura, James Shiniti Nagai, Stijn N. R. Fuchs, Gerjanne Vroeg in de Wei, Inge Snoeren, Giulia Cesaro, I. A. J. M. Bakker, Marta Gargallo Garasa, Jessica Ellen Pritchard, Tesa Klenovšek, Stephani Schmitz, Lina Schmidt, Eric Bindels, Twan Lammers, , Rebekka K. Schneider
This study identifies Spp1⁺ macrophages as key hubs coordinating fibrotic remodeling in myeloproliferative neoplasms using NicheSphere, a novel computational method for cell communication analysis.
bioRxiv · Mar 18, 2026 · PreprintCancer Biology