A viral SAVED protein with ring nuclease activity degrades the CRISPR second messenger cA4
Marta Orzechowski, Ville Hoikkala, Haotian Chi, Stephen McMahon, T.M. Gloster, Malcolm F. White
The paper shows that a viral SAVED domain, AcrIII-2, degrades the CRISPR second messenger cA4, inhibiting its effectors.
Biochemical Journal · Nov 1, 2025Peer-reviewedBiochemistry