Author
University of St AndrewsORCID 0000-0003-3995-3215Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Noora Poikela, Ville Hoikkala, Michael Gordon Ritchie, Maaria Kankare
This study examines a chromosomal inversion in Drosophila montana, finding it enriched with adaptive and barrier loci, suggesting inversions help maintain adaptive allelic combinations and reduce gene flow.
Haotian Chi, Ville Hoikkala, Stephen A. McMahon…·Malcolm F. White
This study describes the structure and mechanism of Crn4, a ring nuclease that degrades cyclic oligoadenylates and modulates type III CRISPR immunity.
Marta Orzechowski, Ville Hoikkala, Haotian Chi…·Malcolm F. White
The paper shows that a viral SAVED domain, AcrIII-2, degrades the CRISPR second messenger cA4, inhibiting its effectors.
Ville Hoikkala, Haotian Chi, Sabine Grüschow…·Malcolm F. White
The paper analyzes type III CRISPR-Cas loci across 38,742 prokaryotic genomes to identify and characterize ring nucleases that regulate cyclic oligoadenylate levels.