LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice
Valeria Uleri, Vojtech Racek, Marta Popovic, Anna Morales Mendez, Veronika Niederlová, Arina Andreyeva, Juraj Michalik, Nadine M. Woessner, Michaela Krupková, Radislav Sedláček, Susana Minguet, Ondřej Štěpánek
This study shows that LCK deficiency in CD8 T cells reduces proliferation but increases effector T-cell formation in mice, revealing its dual role in T-cell responses.
bioRxiv · Aug 28, 2025 · PreprintImmunology