Author

Michaela Krupková

Czech Academy of Sciences, Institute of Molecular GeneticsORCID 0000-0002-9371-2511Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Anna Morales MendeziD· 2 shared Juraj MichalikiD· 2 shared Ondřej ŠtěpánekiD· 2 shared Radislav SedláčekiD· 2 shared Veronika NiederlováiD· 2 shared Vojtech Racek· 2 shared Alena MoudráiD· 1 shared Ales DrobekiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersImmunology

Anna Morales MendezORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 10, 2026

Distinct activation programs in naive and memory CD8 T cells govern stemness and effector persistence of their progeny

Eva Šályová, Darina Paprčková, Juraj Michalik…·Ondřej Štěpánek

The paper shows that prior antigen exposure redirects CD8 T-cell activation programs, shaping progeny fate and persistence through distinct stemness and effector programs in naive and memory cells.

DOI 10.64898/2026.07.22.740179

mousebulk RNA-seq

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ImmunologybioRxivPreprintAug 28, 2025

LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice

Valeria Uleri, Vojtech Racek, Marta Popovic…·Ondřej Štěpánek

This study shows that LCK deficiency in CD8 T cells reduces proliferation but increases effector T-cell formation in mice, revealing its dual role in T-cell responses.

2 citations

mouseexperimental assay

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