Distinct activation programs in naive and memory CD8 T cells govern stemness and effector persistence of their progeny
Eva Šályová, Darina Paprčková, Juraj Michalik, Veronika Niederlová, Veronika Cimermanova, Kateřina Tomicová, Ales Drobek, Vojtech Racek, Alena Moudrá, Anna Kratochvilova, Michaela Krupková, Radislav Sedláček, Ondřej Štěpánek
The paper shows that prior antigen exposure redirects CD8 T-cell activation programs, shaping progeny fate and persistence through distinct stemness and effector programs in naive and memory cells.
bioRxiv · Sep 10, 2026 · PreprintImmunology