BRCA mutation alters the stromal landscape in normal ovaries
Het T. Vaishnav, Alyssa Murray, Olivia R. Piccolo, Curtis W. McCloskey, Edward Yakubovich, Elizabeth A. Macdonald, Maryam Echaibi, Manon de Ladurantaye, Euihye Jung, Thomas J. Fazio, Dominique Trudel, Anne‐Marie Mes‐Masson, Ronny Drapkin, David A. Landry, Barbara C. Vanderhyden
This study shows BRCA mutations alter ovarian stromal structure by promoting fibroblast senescence and myofibroblastic transformation, creating a metastatic niche for early ovarian cancer.
bioRxiv · Oct 1, 2025 · PreprintMolecular Biology