Author

Het T. Vaishnav

Ottawa Hospital Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Almer M. van der SlootiD· 1 shared Alyssa Murray· 1 shared Anne‐Marie Mes‐MassoniD· 1 shared Barbara C. VanderhydeniD· 1 shared Brian K. CoombesiD· 1 shared Curtis W. McCloskeyiD· 1 shared D. William CameroniD· 1 shared Damian M. CarragheriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Almer M. van der SlootORCID

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Author profile →

2 papers

Recent·Most cited

BRCA mutation alters the stromal landscape in normal ovaries

Het T. Vaishnav, Alyssa Murray, Olivia R. Piccolo, Curtis W. McCloskey, Edward Yakubovich, Elizabeth A. Macdonald, Maryam Echaibi, Manon de Ladurantaye, Euihye Jung, Thomas J. Fazio, Dominique Trudel, Anne‐Marie Mes‐Masson, Ronny Drapkin, David A. Landry, Barbara C. Vanderhyden

This study shows BRCA mutations alter ovarian stromal structure by promoting fibroblast senescence and myofibroblastic transformation, creating a metastatic niche for early ovarian cancer.

bioRxiv · Oct 1, 2025 · PreprintMolecular Biology

Engineered spermidine-secreting Saccharomyces boulardii ameliorate colitis and colon cancer in mice

Mahdi Mohaqiq, Roger Palou, Ruizhen Li, Guijun Zhang, Het T. Vaishnav, Florance Parweez, Terence N. Moyana, Damian M. Carragher, D. William Cameron, Tim Ramsay, Almer M. van der Sloot, Sanjay K. Murthy, Brian K. Coombes, Mike Tyers, X. Johné Liu

This study engineers S. boulardii to secrete spermidine, showing improved efficacy in reducing colitis and colon cancer in mice compared to wild-type strains.

Scientific Reports · Aug 30, 2025Peer-reviewedCancer Biology