Engineering CD3 Subunits with Endoplasmic Reticulum Retention Signal Facilitates Allogeneic CAR T Cell Production
Hamidreza Ebrahimiyan, Ali Sayadmanesh, Mahdi Hesaraki, Marzieh Ebrahimi, Hossein Baharvand, Mohsen Basiri
This paper develops a method to reduce TCR expression in CAR T cells using engineered CD3 subunits with an endoplasmic reticulum retention signal, avoiding genome editing and enabling safer allogeneic CAR T cell production.
International Immunopharmacology · Mar 7, 2025Peer-reviewedImmunology