Author

Mahdi Hesaraki

Royan InstituteORCID 0000-0001-7082-2446Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Ali SayadmaneshiD· 1 shared Hamidreza EbrahimiyaniD· 1 shared Hossein BaharvandiD· 1 shared Marzieh Ebrahimi· 1 shared Mohsen BasiriiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperImmunology

Ali SayadmaneshORCID

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1 paper

Recent·Most cited

ImmunologyInternational ImmunopharmacologyPeer-reviewedMar 7, 2025

Engineering CD3 Subunits with Endoplasmic Reticulum Retention Signal Facilitates Allogeneic CAR T Cell Production

Hamidreza Ebrahimiyan, Ali Sayadmanesh, Mahdi Hesaraki…·Mohsen Basiri

This paper develops a method to reduce TCR expression in CAR T cells using engineered CD3 subunits with an endoplasmic reticulum retention signal, avoiding genome editing and enabling safer allogeneic CAR T cell production.

3 citations

humanCITE-seq

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